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Cleaved-KLK8 (V33) pAb

Cleaved-KLK8 (V33) pAb

Cat no: BS7042

Supplier: Bioworld Technology, Inc.
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Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity. Two isoforms exist for this protein. Isoform 1 is the primary form of KLK8 found predominantly in the pancreas. Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predominantly expressed in adult brain and hippocampus. Isoform 2 is not common to the mouse homolog or other primate homologs. In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain. Both isoforms are detected in fetal brain and placenta. In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.
Catalogue number: BS7042
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O60259
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 11-60 of Human KLK8.
Species: Cleaved-KLK8 (V33) pAb detects endogenous levels of Cleaved-KLK8 (24 kDa) protein and Pro-KLK8 (28 kDa) Protein.
Molecular weight: ~ 24, 28 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Kallikrein-8; Hk8; Neuropsin; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; KLK8; NRPN; PRSS19; TADG14; UNQ283; PRO322; Kallikrein 8; Kallikrein8
Additional info: For research use only, not for use in diagnostic procedure.

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