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Cleaved-Notch 2 (D1733) Polyclonal Antibody

Cat no: ABP50052

Cleaved-Notch 2 (D1733) Polyclonal Antibody

NOTCH2 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined.Notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. Notch 2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for NOTCH2.

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SPECIFICATIONS

Catalog Number

ABP50052

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Gene Id

4853

Isotype

Rabbit IgG

Accession

Q04721

Clonality

Polyclonal

Concentration

1 mg/ml

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