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CLEC4E (C-type lectin domain family 4, member E)

CLEC4E (C-type lectin domain family 4, member E)

Cat no: C5839-66

Supplier: United States Biological
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CLEC4E is a diverse family of protein which was originally defined by their ability to recognize a wide range of ligand of carbohydrate structure. CLEC4E expressed in macrophages subjected to several types of stress. It plays an essential role in response to trehalose-6,6'-dimycolate (TDM) and activated by a synthetic analogue, trehalose dibehenate (TDB). Recently it was reported that CLEC4E is associated with an immunoreceptor tyrosine-based activation motif-containing Fc receptor gamma-chain (FcR-gamma) and functions as an activating receptor for damaged self- and non-self-pathogenic fungi. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (Paraffin): 1:50. Incubated for 2 hours at RT. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB). Immunofluorescence (IF-IC): 1:500 Optimal dilutions to be determined by the researcher. Hybridoma: Mouse F0 myeloma cells with spleen cells from BALB/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5839-66
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by Protein G affinity chromatography. ((same/more than)95% SDS-PAGE)
References: 1. Ishikawa E, et al. (2009) J Exp Med, 206(13):2879-88. 2. Matsunaga I, et al. (2009) J Exp Med, 206(13):2865-8. 3. Graham LM, et al. (2009) Cytokine, 48(1-2):148-55.
Additional info: Recognizes human CLEC4E.

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