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CLNS1A, Recombinant, Human, aa1-237, His-Tag (Methylosome Subunit pICln, CLCI, CLNS1B, ICln)

Cat no: 138635

CLNS1A, Recombinant, Human, aa1-237, His-Tag (Methylosome Subunit pICln, CLCI, CLNS1B, ICln)

CLNS1A, also as known as, Methylosome subunit pICln, belongs to the pICln (TC 1.A.47) family. CLNS1A protein has functions in multiple regulatory pathways. This protein interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. It is Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. And this protein is also found associated with the plasma membrane where it functions as a chloride current regulator. \n\nSource:\nRecombinant protein corresponding to aa1-237 from human CLNS1A at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~28.8kD (261aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSHMSFLKS FPPPGPAEGL LRQQPDTEAV LNGKGLGTGT LYIAESRLSW LDGSGLGFSL EYPTISLHAL SRDRSDCLGE HLYVMVNAKF EEESKEPVAD EEEEDSDDDV EPITEFRFVP SDKSALEAMF TAMCECQALH PDPEDEDSDD YDGEEYDVEA HEQGQGDIPT FYTYEEGLSH LTAEGQATLE RLEGMLSQSV SSQYNMAGVR TEDSIRDYED GMEVDTTPTV AGQFEDADVD H\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138635

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.1M sodium chloride, 2mM DTT, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Pu W.T., et al. (1999) Mol. Cell. Biol. 19:4113-4120 2. Friesen W.J., et al. (2001) Mol. Cell. Biol. 21:8289-8300.

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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