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CLOCK

CLOCK

Cat no: C5843-01A

Supplier: United States Biological
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CLOCK, a basic helix-loop-helix (bHLH)/PAS protein, is an important factor in the molecular clock mechanism. Mutations in this protein lead to abnormal circadian behavior and defective transcriptional activity. CLOCK has been shown to interact strongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform. Applications: Suitable for use in Western Blot and Chromatin Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5843-01A
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: 5330400M04Rik, Circadian locomoter output cycles protein kaput, mCLOCK, mKIAA0334
References: 1. Hogenesch, JB., et al. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci USA. 95(10):5474-9, 1998. 2. Dunlap, Jay. An End in the Beginning. Science. 280: 1548-49, 1998. 3. Jin, X., et al. A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock. Cell. 96: 57-68, 1999. 4. Shearman, L.P. and D.R. Weaver. Photic induction of Period gene expression is reduced in Clock mutant mice. Neuroreport. 10(3): 613-618, 1999.
Additional info: Recognizes mouse CLOCK. Species Crossreactivity: human

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