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Clostridium botulinum A Toxin (aa1280-1292)

Clostridium botulinum A Toxin (aa1280-1292)

Cat no: C5851-40D

Supplier: United States Biological
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Clostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln--Arg-198 bond of SNAP-25. Applications: Suitable for use in ELISA, Immunofluorescence, RIA and Immunocytochemistry. Other applications have not been tested. Recommended Dilutions: Immunocytochemistry: 1:50 Optimal dilutions to be determined by the researcher. Control Peptide: C5851-40D1, Clostridium botulinum A Toxoid (aa1280-1292). Prior incubation of the antibody with the control peptide has been shown to eliminate the inhibition of cellular binding by the antibody. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5851-40D
Hosts: Mouse
Applications: ELISA, Immunocytochemistry, Immunofluorescence
Size: 500ul
Form: Supplied as a liquid. No preservatives added
P type: Mab
Isotype: IgG
Purity: Supernatant
Additional info: Recognizes and binds to intact whole C. botulinum Toxin A, aa1280-1292. Has been found to stain Neuro2A cells treated with GT1b ganglioside prior to the addition of C. botulinum Toxin A. Inhibits the entry of C. botulinum Toxin A to Neuro2A cells treated with GT1b ganglioside prior to the addition of the toxin. Cross-reactivity: C. botulinum Toxin A (1280-1292) and C. botulinum Toxin A: 100%, C. botulinum Toxin B, C, E and F(1272-1280): 0%

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