Clusterin (human) Competitive BioAssay(TM) ELISA Kit (TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SPG-2)

Clusterin (Apolipoprotein J; ApoJ; SP-40,40; Sulfated glycoprotein-2; SGP-2) is a heterodimeric highly conserved disulfide-linked multifunctional glycoprotein being expressed in a wide variety of tissues and secreted in all human fluids. Clusterin is supposed to have a protective role against human atherosclerosis. In patients with type 2 diabetes mellitus serum clusterin levels are significantly higher than in healthy individuals. Furthermore, body fluids level of clusterin from patients with malignant tumors, such as breast cancer, bladder cancer and prostate cancer, are elevated. Variants of the CLU gene are associated with Alzheimer's disease. CLU expression is increased in Alzheimer's disease patients. In summary, clusterin likely provides a promising novel diagnostic marker in many major human diseases like diabetes, cancers or neurodegenerative diseases.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C

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SPECIFICATIONS

Catalog Number

044668

Size

96Tests

References

Product Reference: \n?A proof-of-principle gel-free proteomics strategy for the identification of predictive biomarkers for the onset of pre-eclampsia: R.T. Blankley, et al.; BJOG 116, 1473 (2009)\n?A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease: H.R. Yu, et al.; Pediatr. Allergy Immunol. 20, 699 (2009)\n?Clusterin in Stool: A New Biomarker for Colon Cancer Screening?: S. Pucci, et al.; Am. J. Gastroenterol. 104, 2807 (2009)\n?Plasma Clusterin Levels in Predicting the Occurrence of Coronary Artery Lesions in Patients With Kawasaki Disease: H.R. Yu, et al.; Pediatr. Cardiol. 31, 1151 (2010)\n?Clusterin and Chemotherapy Sensitivity Under Normoxic and Graded Hypoxic Conditions in Colorectal Cancer: D. Kevans, et al.; J. Gastrointest. Cancer (Epub ahead of print) (2011)\n?

Additional Info

Detects human clusterin. Does not cross-react with mouse clusterin.

Alternative Names

TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SPG-2