CNP, ID (2',3'-cyclic-nucleotide 3'-phosphodiesterase, CNPase)

Cat no: C6200-01H

Supplier: United States Biological

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CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kD (CNP1) and 48kD (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:3000 Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C6200-01H
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	50ul
Form:	Supplied as a liquid in 0.1M Tris-glycine, pH 7.0, 0.01% thimerosal, 10% glycerol.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes human CNP. Species sequence homology: Mouse (82%), rat (84%), bovine (89%), monkey (97%).

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CNP, ID (2',3'-cyclic-nucleotide 3'-phosphodiesterase, CNPase)

Cat no: C6200-01H

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