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CNPase (CNP, 2',3'-cyclic Nucleotide 3'-phosphodiesterase)

CNPase (CNP, 2',3'-cyclic Nucleotide 3'-phosphodiesterase)

Cat no: C6200-01G

Supplier: United States Biological
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2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is associated with brain tubulin and acts as a microtubule-associated protein in promoting microtubule assembly and distribution. CNPase is used as a marker of cell differentiation in the CNS as it is expressed primarily in committed oligodendroglial progenitors and terminally-differentiated oligodendrocytes. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Normal human brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C6200-01G
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ishii, T., Ohsugi, K., Nakamura, S., Sato, K., Hashimoto, M., Mikoshiba, K. and Sakuragawa, N. Gene expression of oligodendrocyte markers in human amniotic epithelial cells using neural cell-type-specific expression system. Neurosci Lett. Jun 25;268(3):131-4 (1999). 2. Staugaitis, S.M., Bernier, L., Smith, P.R. and Colman, D.R. Expression of the oligodendrocyte marker 2'3'-cyclic nucleotide 3'-phosphodiesterase in non-glial cells. J. Neurosci. Res. 25(4), 556-560 (1990). 3. Thompson, R.J. 2',3'-cyclic nucleotide-3'-phosphohydrolase and signal transduction in central nervous system myelin. Biochem. Soc. Trans. 20(3), 621-626 (1992). 4. Douglas, A.J., Fox, M.F., Abbott, C.M., Hinks, L.J., Sharpe, G., Povey, S. and Thompson,R.J. Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene. Ann. Hum. Genet. 56(PT 3), 243-254 (1992).
Additional info: Recognizes aa68-84 [RVIVDKYRDGTKMVSAD] of human, CNPase. Species Crossreactivity: mouse and rat.

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