Home  >  Products  >  Cofilin 2, CT (Cofilin-2, CFL2, Cofilin 2 Muscle, Muscle Cofilin, Cofilin Muscle Isoform, HGNC:1875, NEM7)
Cofilin 2, CT (Cofilin-2, CFL2, Cofilin 2 Muscle, Muscle Cofilin, Cofilin Muscle Isoform, HGNC:1875, NEM7)

Cofilin 2, CT (Cofilin-2, CFL2, Cofilin 2 Muscle, Muscle Cofilin, Cofilin Muscle Isoform, HGNC:1875, NEM7)

Cat no: C7506-50F

Supplier: United States Biological
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Cofilin 2 is expressed in developing skeletal muscle at early fetal stages through to a young postnatal stage. During postnatal development, cofilin 1 expression in muscle is down-regulated and cofilin 2 becomes the only isoform in mature skeletal muscle. The onset of cofilin 2 expression is coupled with terminal differentiation of muscle cells. It is suggested that cofilin 2 could be associated with actin filaments in muscle cells more efficiently than cofilin 1. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.01-0.3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7506-50F
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.3, 0.02% sodium azide, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Nakashima, K et al. (2005) Two mouse cofilin isoforms, muscle-type (MCF) and non-muscle type (NMCF), interact with F-actin with different efficiencies. J. Biochem. (Tokyo). 138: 519-526.
Additional info: Recognizes an epitope within the C-terminal (CT) of cofilin 2. Species Crossreactivity: mouse, rat, sheep, dog and pig.

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