Home  >  Products  >  Cohesin, hRad21 (Double strand break repair protein rad21 homolog, hHR21, HR21, HRAD21, MCD1, Nuclear matrix protein 1, NXP1, Scc1)
Cohesin, hRad21 (Double strand break repair protein rad21 homolog, hHR21, HR21, HRAD21, MCD1, Nuclear matrix protein 1, NXP1, Scc1)

Cohesin, hRad21 (Double strand break repair protein rad21 homolog, hHR21, HR21, HRAD21, MCD1, Nuclear matrix protein 1, NXP1, Scc1)

Cat no: C7506-98A

Supplier: United States Biological
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The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2). Cellular Localization: Nuclear and cytoplasm Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7506-98A
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1,k
Purity: Purified
Alternative names: Double strand break repair protein rad21 homolog, hHR21, HR21, HRAD21, MCD1, Nuclear matrix protein 1, NXP1, Scc1
Additional info: Specific for both the nuclear hRad21 protein and the cleaved cytoplasmic hRad21 protein. Species Crossreactivity: human and mouse cohesin (Rad21) protein. Other species have not been tested.

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