Coilin (p80, COIL, CLN80)

Cat no: C7506-98K

Supplier: United States Biological

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Description
Additional Information

Coilin is a component of the nuclear Cajar(coiled) bodies (CBs) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. Human coilin is a 576aa protein found enriched in CBs, but is also found in large amounts in the nucleoplasm. Coilin is a constitutive phosphoprotein that is hyperphosphorylated during mitosis and it is thought that hyperphosphorylation triggers CB disassembly during cell replication. Self-interaction and localization have been shown to depend on the phosphorylation state of coilin. Applications: Suitable for use in Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunoprecipitation: 2ul Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C7506-98K
Reactivities:	Human
Hosts:	Mouse
Applications:	Immunoprecipitation
Size:	100ul
Form:	Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
P type:	Mab
Isotype:	IgG1,k
Purity:	Ascites
References:	1. Lam YW, Lyon CE, Lamond AI. (2002) Mol.Biol.Cell. 13:2461-2473. 2. Carmo-Fonseca M. Et al. (1993) J Cell Biol. 120:841-852.
Additional info:	Recognizes human Coilin.

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Coilin (p80, COIL, CLN80)

Cat no: C7506-98K

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