Colistin sulfate (USP Grade) (Polymyxin E, Belcomycin, Colimycin)

Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections. \n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C\nStable for at least 2 years after receipt when stored at +4 degrees C.

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SPECIFICATIONS

Catalog Number

044677

Size

100mg

Purity

Mixture (primarly colistin A and B).

References

Product Reference: \nAntimicrobial drugs, microorganisms, and phagocytes: P.J. van den Broek; Rev. Infect. Dis. 11, 213 (1989) (Review)?\nPolymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999) (Review)?\nThe clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001) (Review)?\nUpdate on antimicrobial agents: new indications of older agents: T.R. Pasquale & J.S. Tan; Expert Opin. Pharmacother. 6, 1681 (2005) (Review)?\nColistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections: J. Li, et al.; Lancet Infect. Dis. 6, 589 (2006) (Review)?\nPolymyxin B: similarities to and differences from colistin (polymyxin E): A. Kwa, et al.; Expert Rev. Anti. Infect. Ther. 5, 811 (2007) (Review)?\nColistin in the 21st century: R.L. Nation & J. Li; Curr. Opin. Infect. Dis. 22, 535 (2009) (Review) ?\nNew information about the polymyxin/colistin class of antibiotics: J. Molina, et al.; Expert Opin. Pharmacother. 10, 2811 (2009) (Review)?\nColistin: new lessons on an old antibiotic: D. Yahav, et al.; Clin. Microbiol. Infect. 18, 18 (2012) (Review)?\n

Alternative Names

Polymyxin E, Belcomycin, Colimycin