Collagen Type I (5D8) Antibody

Cat no: 250274

Supplier: ABBIOTEC

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Description
Additional Information

Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matri, Xenopus/Amphibian,. Defects in one or both alleles of the type I collagen gene causes "brittle bone disease" (osteogenesis imperfecta). Patients suffering from such defects have low levels of fully functional type I collagen resulting in fragile bones. This antibody is highly specific for native type I collagen and shows no evidence of cross-reactivity with type II, III, V and VI collagens in inhibition ELISA and immunoblotting, and no evidence of cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). The antibody reacts with human, calf, sheep,Porcineig, dog and goat type I collagens in ELISA and immunoblotting, but does not react with mouse, guinea pig, cat, rabbit, squirrel, horse, kangaroo or chicken type I collagen. The antibody has a Ka of appro, Xenopus/Amphibian,imately 2.5 , Xenopus/Amphibian, 106 M-1 for human type I collagen.

Catalogue number:	250274
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.2 mg
Accession:	P02452
Antigen:	Pepsin-solubilized, salt-fractionated type I collagen from human placenta
Format:	Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1/k
Clonality:	5D8
Additional info:	Collagen alpha-1(I) chain; alpha-1 type I collagen; COL1A1