Collagen Type I, Digested (Collagen Type 1, Alpha-1 Type I Collagen, Collagen alpha-1(I) Chain, Collagen Type I alpha 1, COL1A1, COLIA1, Alpha-2 Type I Collagen, Collagen alpha-2(I) Chain, Collagen Type I alpha 2, COL1A2, Collagen Of Skin Tendon And Bone,

Collagens play a dominant role in maintaining the structural integrity of organs and tissues (1), but they also regulate cell polarity, migration, survival and phenotype, and provide diffusible signaling molecules following breakdown (2). Within the family of collagens that currently comprises 21 members, type I collagen is included in the group of fibril-forming collagens based on its structural and functional features. Type I collagen is ubiquitous in all vertebrates and is among the largest and most complex of all macromolecules. It accounts for 80-90% of all collagenous proteins in skin (3). The helical trimeric molecules of type I collagen compromise two alpha1(I) chains and one alpha2(I) chain, encoded by two separate genes Col(I)a1 and Col(I)a2, respectively (3). Matrix metalloproteinase (MMP)-1,-8, -13 and -14 cleave the peptide\nbonds between residues Gly775 and Ile776 of the alpha1(I) chain and Gly775 and Leu776 of the alpha2(I) chains, resulting in

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SPECIFICATIONS

Catalog Number

C7510-16D

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 100mM Tris-HCl, pH 8, 0.05% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgM

References

1. Vuorio and Crombrugghe. The family of collagen genes. Annu. Rev. Biochem. 1990;59: 837-872. 2. Egeblad and Werb. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer. 2002;2: 161-174 3. Kielty et al. The Collagen family: Structure, assembly, and organization in the extracellular matrix. In Connective tissue and its inheritable disorders. P.M. Royce and B. Steinmann, editors. Wiley-Liss, New York. 1993; 103-147.

Additional Info

Recognizes human Collagen Type I, Digested. Does not cross react with human type IV collagen.