Type I collagen is the major structural component of extracellular matrices found in connective tissue and internal organs, but is most prevalent in the dermis, tendons, and bone. It is a 300kD molecule composed of two alpha 1 chains and one alpha2 chain that spontaneously forms a triple helix scaffold when at a neutral pH and 37 degrees C. This phenomenon can be exploited to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development.
Applications: