Collagen Type I, Rat Tail (Collagen Type 1, Collagen Of Skin Tendon And Bone, Alpha 1 Type I Collagen, COL1A1, Collagen I alpha 2 Polypeptide, COL1A2, Osteogenesis Imperfecta Type IV, OI4, Pro alpha 1(I) Collagen, Type I Procollagen)

Cat no: C7510-18

Supplier: United States Biological

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Type I collagen is the major structural component of extracellular matrices found in connective tissue and internal organs, but is most prevalent in the dermis, tendons, and bone. It is a 300kD molecule composed of two alpha 1(I) chains and one alpha2(I) chain that spontaneously forms a triple helix scaffold when at a neutral pH and 37 degrees C. This phenomenon can be exploited to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. Quality Control: Tested for uniform gelation and for attachment of and spreading of HT-1080 human fibrosarcoma cells. Negative for the presence of mycoplasma, bacteria and fungi. Technical Notes: 1. Typically if the rat tail collagen's concentration goes below 0.4mg/ml, there will be little to no gelation. 2. Higher pH can also interfere with the gelling of this product. Storage and Stability: May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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Catalogue number:	C7510-18
Size:	25mg
Form:	Supplied as a liquid in 20mM acetic acid.
Purity:	Quality Control: Tested for uniform gelation and for attachment of and spreading of HT-1080 human fibrosarcoma cells. Negative for the presence of mycoplasma, bacteria and fungi. Endotoxin: (same/less than) 20EU/ml by LAL assay
References:	1. Chen, S., et al., Stem Cells 21: 281-295 (2003). 2. Kokenyesi, R., et al., Gynecol Oncol. 89: 60-72 (2003). 3. Kutznetsova, N., et al., Biochem. 37: 11,888-11,895 (1998). 4. Kutznetsova, N. and S. Leikin, S., J. Bio. Chem. 274: 36,083-36,088 (1999). 5. Leikin, S., et al., Proc. Natl. Acad. Sci. USA. 91: 276-280 (1994). 6. Leikina, E., et al., Proc. Natl. Acad. Sci. USA. 99: 1314-1318 (2002). 7. O

Collagen Type I, Rat Tail (Collagen Type 1, Collagen Of Skin Tendon And Bone, Alpha 1 Type I Collagen, COL1A1, Collagen I alpha 2 Polypeptide, COL1A2, Osteogenesis Imperfecta Type IV, OI4, Pro alpha 1(I) Collagen, Type I Procollagen)

Cat no: C7510-18

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