Type II Collagen is the principal collagenous component of cartilage, intervertebral disc and vitreous humour. It is also found in other tissues during development. Its main function is to provide tensile strength and give cartilage the ability to resist shearing forces. Type II Collagen supports chondrocyte adhesion and may influence the differentiated phenotype of these cells. It can also be used as an in vivo model in rats and mice for arthritis studies (injection of Bovine Collagen II induces arthritis).
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilutions:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.