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Collagen Type II

Cat no: C7510-20D


Supplier: United States Biological
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Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody CIIC1 has been shown to induce CAIA in na
Catalogue number: C7510-20D
Reactivities: Human, Mouse, Rat, Bovine, Chicken/Bird
Hosts: Mouse
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
Alternative names: CII, J1 epitope
References: 1. Nandakumar, K et al; Collagen Type II-specific monoclonal antibody-induced arthritis in mice. Description of the disease and the influence of age, sex and genes. Am J Pathol 2003, 163: 1827 2. Nandakumar, K et al; Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther 2004, 6: R544
Additional info: Recognizes the J1 epitope (triple helical position 551-564) of collagen type II. Species crossreactivity: rat, bovine, chicken, human

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