Collapsin Response Mediator Protein 4 (CRMP4, DPYSL3, DRP-3, DRP3, ULIP, Dihydropyrimidinase-like 3)

DRP-3 belongs to the hydantoinase/dihydropyrimidase subfamily. It is required for signalling by class 3 semaphorins and remodelling of the cytoskeleton. It also plays a role in axon guidance, neuronal growth cone collapse and cell migration. It exists as a homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. The unprocessed precursor is 570 amino acids long and has an estimated molecular weight of 61.9kD. It is mainly expressed in heart and skeletal muscle, but is also strongly expressed in fetal brain and spinal cord. It localizes to the cytoplasm and growth cone. This protein interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.\n\nApplications:\nSuitable for use in Direct ELISA and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability: \nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7517-08H

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.

P Type

Mab

Purity

Purified by affinity chromatography.

Isotype

IgG

Additional Info

Recognizes human DRP-3. Species Crossreactivity: mouse and rat.

Alternative Names

Dihydropyrimidinase-related protein 3, unc-33-like phoshoprotein, ULIP protein, collapsin response mediator protein 4, CRMP-4, GENE NAME: DPSYL3, CRMP4, DRP3, ULIP