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COMMD1, aa1-190, Recombinant, Human (C2orf5, COMM Domain-containing Protein 1, MGC27155, MURR1, Protein Murr1)

Cat no: C7847-51

COMMD1, aa1-190, Recombinant, Human (C2orf5, COMM Domain-containing Protein 1, MGC27155, MURR1, Protein Murr1)

COMMD1, also known as copper metabolism MURR1 domain-containing protein 1, is a 190aa protein responsible for inhibition of TNF-induced NFkB p50 and has a suggested role in facilitation of biliary copper excretion within hepatocytes. High expression is found in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. This protein interacts directly with COMMD6 and ATP7B, and indirectly with IkB-B and COMMD7. \n\nSource:\nRecombinant corresponding to aa1-190 of human COMMD1 6x his tagged, expressed in E.coli. \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFNQLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN\n\nMolecular Weight: 23.3kD (210aa), confirmed by MALDI-TOF\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7847-51

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 20% glycerol, 0.1M sodium chloride.

Purity

~90% (SDS-PAGE).

References

1. Van De Sluis B, et al. (2002) Hum Mol Genet. 11(2):165-73. 2. M

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

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Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

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Applications

ELISA

Hosts

Mouse

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