Complement 1s (Complement Component 1 s Subcomponent, Basic Proline-rich Peptide IB-1, C1 Esterase, Complement C1s Subcomponent Precursor)

C1 component of human complement is a complex of three glycoproteins: C1q, C1r and C1s. C1s has a molecular weight of 83000 and is present in plasma in an average concentration of 50mg/ml, either as a complex with C1q and C1s or in the absence of C1q as a tetramer with C1s. The subcomponents of the C1 complex are responsible for the initiation of the classical pathway of complement activation. \n\nApplications: \nSuitable for use in use ELISA, Immunoelectrophoresis and Radial Immunodiffusion. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7850-08J

Size

1ml

Applications

ELISA

Hosts

Goat

Reactivities

Hum

Form

Supplied as a lyophilized powder. Preservative free. Reconstitute with 1ml sterile ddH2O. Dilute further in PBS, pH 7.2.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Recognizes human C1s. In immunoelectrophoresis and radial immunodiffusion (Ouchterlony) against fresh normal human plasma a single precipitin line is obtained which shows a reaction of identity with the precipitin line obtained with purified C1s protein. May also react with complexes containing C1q. No reaction is obtained with C1q, C1r or any other plasma protein component or serum. Does not crossreact with any other component of human plasma.