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Complement C1q (Complement Component 1, q Subcomponent)

Complement C1q (Complement Component 1, q Subcomponent)

Cat no: C0010-02E

Supplier: United States Biological
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Human complement component 1, q subcomponent (C1q) is a 156kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis. Applications: Suitable for use in ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (frozen) amd Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:500-1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C0010-02E
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in borate buffered saline, pH 8.4, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes human complement component 1, q subcomponent (C1q) at 156kD. In immunohistochemistry strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).

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