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Complement C1r (C1r, C1-R, Complement C1r Subcomponent, Complement Component 1 r Subcomponent)

Complement C1r (C1r, C1-R, Complement C1r Subcomponent, Complement Component 1 r Subcomponent)

Cat no: C7850-07C

Supplier: United States Biological
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C1 component of human complement is a complex of three glycoproteins: C1q, C1r and C1s. C1r has a molecular weight of 83000 and is present in plasma in an average concentration of 50mg/ml, either as a complex with C1q and C1s or in the absence of C1q as a tetramer with C1s. The subcomponents of the C1 complex are responsible for the initiation of the classical pathway of complement activation. Applications: Suitable for use in ELISA, Immunoelectrophoresis and Radial Immunodiffusion. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7850-07C
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 1ml
Form: Supplied as a lyophilized powder. Preservative free. Reconstitute with 1ml sterile ddH2O.
P type: Pab
Isotype: IgG
Purity: Serum
Additional info: Recognizes human C1r. . In immunoelectrophoresis and radial immunodiffusion (Ouchterlony), against fresh normal human plasma a single precipitin line is obtained which shows a reaction of identity with the precipitin line obtained with purified C1r protein. Complexes containing C1q may also react with the antiserum. No reaction is obtained with C1q, C1s or any other plasma protein component or serum. Does not crossreact with any other component of human plasma.

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