Home  >  Products  >  Complement C3, C3a (Complement C3 alpha Chain, Complement Component C3a, C3/C3a, C3a Anaphylatoxin, Acylation Stimulating Protein, ASP, Complement Component 3, Complement Factor 3)
Complement C3, C3a (Complement C3 alpha Chain, Complement Component C3a, C3/C3a, C3a Anaphylatoxin, Acylation Stimulating Protein, ASP, Complement Component 3, Complement Factor 3)

Complement C3, C3a (Complement C3 alpha Chain, Complement Component C3a, C3/C3a, C3a Anaphylatoxin, Acylation Stimulating Protein, ASP, Complement Component 3, Complement Factor 3)

Cat no: C7850-13B2

Supplier: United States Biological
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Complement component 3a (C3a) is present in the blood serum. C3a is generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3a and C3b, which is further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. C3a mediates local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3a is expressed at significantly higher levels in colorectal cancer. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1500-1:6,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7850-13B2
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ul
Form: Supplied as a liquid in borate buffered saline, pH 8.2, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: Plp
Additional info: Recognizes human complement component 3a (C3a) at ~9kD. Minimal reactivity with other complement proteins in radioimmunoassays and hemagglutination.

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