Complement C5 (Complement Component C5, Anaphylatoxin C5a Analog, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 4, CPAMD4)

C5 is synthesized in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kD glycoprotein consisting of disulfide-linked alpha chain (115kD) and beta chain (75kD). It occurs in plasma at about 75mg/ml. C5 is activated, via either the classical or alternative complement pathway, by protoelytic cleavage of C5a (11.5kD) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b, initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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