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Complement Factor B (C3/C5 Convertase, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B, CFB, BF, BFD)

Complement Factor B (C3/C5 Convertase, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B, CFB, BF, BFD)

Cat no: C7850-60K

Supplier: United States Biological
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Complement factor B is a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: KT21: 5ug/ml as coating antibody KT24 peroxidase: 1:1,000 dilution Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7850-60K
Reactivities: Human
Hosts: Mouse
Applications: ELISA
Size: 100ug
Form: KT21: Supplied as a liquid in PBS, 0.1% sodium azide. KT24 peroxidase: Supplied as a liquid in PBS, 0.01% thimerosal.
P type: Mab
Isotype: IgG2b+IgG1
Purity: Ascites
Additional info: Recognizes human complement Factor B Capture/detection antibody pairs: KT21/KT24 peroxidase.

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