Home  >  Products  >  Complement Factor Bb (Complement Factor B Bb Fragment, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B)
Complement Factor Bb (Complement Factor B Bb Fragment, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B)

Complement Factor Bb (Complement Factor B Bb Fragment, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B)

Cat no: C7850-68

Supplier: United States Biological
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Factor B is present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit) leaving the 63kD Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation. Applications: Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7850-68
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Western Blot
Size: 100ug
Form: Supplied as a liquid in borate buffered saline, 0.02% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
Alternative names: Complement Factor B, C3/C5 Convertase, Glycine-rich beta-glycoprotein
References: 1. Xu, Y. et al. (2001) Structural biology of the alternative pathway convertase. Immunol. Rev. 180:123-135, 2. Ponnuraj, K. et al. (2004) Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol. Cell. 14:17-28.
Additional info: Recognizes human Complement Factor Bb. Reacts with a neoantigen of the Bb fragment of human complement factor B.

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