Complement Factor P (CFP, BFD, Factor P, PFC, PFD, Properdin, Properdin P Factor Complement)

Factor P is a 53kD glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.\n\nApplications:\nSuitable for use in ELISA, Functional Assays and Immunohistochemistry. Other applications not tested. \n\nRecommended Dilutions:\nImmunohistochemistry: Frozen sections\nOptimal dilutions to be determined by the researcher. \n\nRecommended Positive Control:\nKidney from post strepoccal glomerulonephritis patients\n\nRecommended Secondary Antibodies:\nI1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo\nI1904-06H: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C7850-95

Size

100ug

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in borate buffered saline, pH 8.2, 0.1% sodium azide

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Hourcade, D. et al. (2006) The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132, 2. Jelezarova, E. et al. (2000) Interaction of C3b2

Additional Info

Recognizes human Complement Factor P.