Isolated from Streptomyces conglobatus, conglobatin has a unusual dimeric macrolide dilactone structure with pendant oxazole groups. It exhibited an IC50 of 0.63 ug/ml in a NFAT-dependent transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.
Purity: >95% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Related to: Elaiophyllin
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