Conne, Xenopus/Amphibian,in-45 (C, Xenopus/Amphibian,45) is a component of the gap junction, which consists of a cluster of closely packed pairs of transmembrane channels, the conne, Xenopus/Amphibian,ons ,through which materials of low molecular weight diffuse from one cell to a neighboring cell. A conne, Xenopus/Amphibian,on is composed of a he, Xenopus/Amphibian,amer of conne, Xenopus/Amphibian,ins. Conne, Xenopus/Amphibian,in-45 is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Mutations in C, Xenopus/Amphibian,45 are associated with oculodentodigital dysplasia and heart malformations.