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Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1)

Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1)

Cat no: C7857-01D

Supplier: United States Biological
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Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy. Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C. Phosphorylation of Ser368 by PKC induces a conformational change of Connexin43 that results in a decrease in gap junction permeability. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7857-01D
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: 10 mM HEPES [pH7.5], 150 mM NaCl 100ug/ml BSA with 50% glycerol
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: Gap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein
References: 1. Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol (Berl) 101:449-459. 2. Bao X, Altenberg GA, Reuss L (2004a) Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation. Am J Physiol Cell Physiol 286:C647- 654. 3. Bao X, Reuss L, Altenberg GA (2004b) Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368. J Biol Chem 279:20058-20066. 4. Yogo K, Ogawa T, Akiyama M, Ishida N, Takeya T (2002) Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells. FEBS Lett 531:132-136.
Additional info: Specific for ~43k Connexin43 protein. Species Crossreactivity: Human, mouse, non-human primates, and rat based on 100% antigen sequence homology.

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