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Connexin 43 (Cx43, Gap Junction alpha 1 Protein, CxA-1, Gap Junction 43kD Heart Protein, GJA1, GJAL)

Connexin 43 (Cx43, Gap Junction alpha 1 Protein, CxA-1, Gap Junction 43kD Heart Protein, GJA1, GJAL)

Cat no: C7857-01H

Supplier: United States Biological
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Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy. Connexin43 (Cx43) forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Cx43 is known to be regulated by phosphorylation at Ser368 by protein kinase C. Phosphorylation of Ser368 by PKC induces a conformational change of Cx43 that results in a decrease in gap junction permeability. Applications: Suitable for use in Western Blot, Immunohistochemistry, and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Immunohistochemistry: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7857-01H
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human Connexin 43. Species Cross-Reactivity: mouse, rat.

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