Home  >  Products  >  Constitutive Androstane Receptor (CAR, CAR BETA CAR1, CARA, Constitutive activator of retinoid response, Constitutive active response, MGC97144, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3 )
Constitutive Androstane Receptor (CAR, CAR BETA CAR1, CARA, Constitutive activator of retinoid response, Constitutive active response, MGC97144, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3 )

Constitutive Androstane Receptor (CAR, CAR BETA CAR1, CARA, Constitutive activator of retinoid response, Constitutive active response, MGC97144, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3 )

Cat no: C7700

Supplier: United States Biological
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Constitutive androstane receptor (CAR) is a member of orphan receptor. CAR is mainly expressed in liver and lower levels of expression are observed in heart, muscles, kidney and lung. CYP3A and CYP2B are regulated by CAR, which suggest xenobiotics can activate multiple CYP genes through this receptor. Mouse homolog is induced by phenobarbital and CAR-null mouse demonstrate resistance to acetaminophen toxicity. CAR affects metabolism of drugs and other xenobiotics. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications have not been tested. Recommended Dilution: Immunoprecipitation: 1:50-1:200 Western Blot: 1:500-1:1000 Optimal dilution to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7700
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Alternative names: CAR, CAR BETA CAR1, CARA, Constitutive activator of retinoid response,Constitutive active response, MGC97144, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3
Additional info: Recognizes endogenouse levels of human CAR.

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