Constitutive Androstane Receptor (CAR, CAR BETA CAR1, CARA, Constitutive activator of retinoid response, Constitutive active response, MGC97144, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3 )

Constitutive androstane receptor (CAR) is a member of orphan receptor. CAR is mainly expressed in liver and lower levels of expression are observed in heart, muscles, kidney and lung. CYP3A and CYP2B are regulated by CAR, which suggest xenobiotics can activate multiple CYP genes through this receptor. Mouse homolog is induced by phenobarbital and CAR-null mouse demonstrate resistance to acetaminophen toxicity. CAR affects metabolism of drugs and other xenobiotics.\n\nApplications:\nSuitable for use in Western Blot and Immunoprecipitation. Other applications have not been tested.\n\nRecommended Dilution:\nImmunoprecipitation: 1:50-1:200\nWestern Blot: 1:500-1:1000\nOptimal dilution to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7700

Size

100ug

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

Additional Info

Recognizes endogenouse levels of human CAR.

Alternative Names

CAR, CAR BETA CAR1, CARA, Constitutive activator of retinoid response,Constitutive active response, MGC97144, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3