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Contactin-associated protein 1 (Caspr1)

Contactin-associated protein 1 (Caspr1)

Cat no: C7865-19A

Supplier: United States Biological
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Contactin-associated protein 1(Caspr) is a single-pass type I membrane protein belonging to the neurexin family and is comprised of one F5/8 type C domain, one fibrinogen C-terminal domain, two EGF-like domains, and four laminin G-like domains. Caspr is well documented for its interaction with contactin, an interaction that is crucial to the transport of Caspr to the plasma membrane, the mylination of glial cells, and the generation of axoglial junctions. Studies also suggest that Caspr may play a regulatory role in the cell surface expression of contactin and its targeting to different axonal domains. Expression of Caspr is largely observed in the brain, mainly in CNS myelinated nerve fibers within paranodal axoglial junctions. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: 1:300 detects Caspr in rat cerebellum and rat hippocampus tissues. Western Blot: 0.5ug/ml detected Caspr on 10ug of rat brain membrane tissue lysate. Optimal dilutions to be determined by the researcher. Positive Control: Rat brain membrane tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7865-19A
Reactivities: Rat
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Alternative names: contactin associated protein 1, neurexin 4, neurexin-4 contactin-associated protein 1, Neurexin IV, Neurexin-4
References: 1. Wolswijk, G., et al. (2003). Brain. 126:1638- 1649. 2. Rios, J., et al. (2000). J. Neurosci. 20:8354. 3. Gollan, L., et al. (2003). J. Cell. Biol. 163:1213.
Additional info: Recognizes rat Caspr. Species sequence homology: mouse 100%.

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