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CoREST (REST corepressor 1, Protein CoREST, KIAA0071, RCOR, RCOR1)

CoREST (REST corepressor 1, Protein CoREST, KIAA0071, RCOR, RCOR1)

Cat no: C7900-80A

Supplier: United States Biological
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Brain type II sodium channels are important in neuronal phenotyping and are only seen at high levels in neurons. Studies have shown that CoREST functions as a corepressor for REST. This interaction between REST and CoREST is accomplished by means of a single zinc finger binding motif originating from REST. Together, the REST-CoREST complex mediates long term repression of the type II sodium channel gene (1). Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7900-80A
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: As reported
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: REST corepressor 1, Protein CoREST, KIAA0071, RCOR, RCOR1
References: 1. Andres,M.E., Burger,C., Peral-Rubio,M.J., Battaglioli,E., Anderson,M.E., Grimes,J., Dallman,J., Ballas,N., Mandel,G. CoREST: a functional corepressor required for regulation of neural-specific gene expression. Proc. Natl. Acad. Sci. U.S.A. 96:9873-9878, 1999.
Additional info: Species Crossreactivity: Human. Other species have not been tested. Reactivity with mouse CoREST is expected owing to conservation of sequence between this ortholog and human CoREST at the site to which the epitope maps.

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