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CoREST (REST Corepressor 1, Protein CoREST, KIAA0071, RCOR, RCOR1)

CoREST (REST Corepressor 1, Protein CoREST, KIAA0071, RCOR, RCOR1)

Cat no: C7900-80C

Supplier: United States Biological
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The regulation of neuronal cell specific gene expression, is dependent on the repression of non-neuronal cell gene transcription, mediated by the neuronal silencer protein REST/NRSF (RE1 silencing transcription factor/neural-restrictive silencing factor) through recruitment of the BHC complex. CoREST is a SANT-domain-containing protein within the BHC complex, which mediates the nucleosomal demethylation of H3K4 (histone H3 lysine 4), and acts as a regulator of BHC corepressor function. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2500-1:5000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7900-80C
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in tris-citrate/phosphate, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lee, M.G. et al. (2005) An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature. 437: 432-435.
Additional info: Recognizes human CoREST (REST corepressor 1). Species sequence homology: mouse.

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