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Cortactin (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)

Cortactin (Src Substrate Cortactin, EMS1, Amplaxin, CTTN, Oncogene EMS1)

Cat no: C7901-85L

Supplier: United States Biological
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Cortactin is a c-src substrate associated with sites of dynamic actin assembly at the leading edge of migrating cells promotes branched actin filament network formation by Arp2:3 complex. Cortactin is an F-actin-binding protein. The amino-terminal half of the protein is comprised of multiple copies of an internal, tandem 37aa repeat while the carboxyl-terminal half contains a distal SH3 domain. Cortactin, present in several different cell types, is enriched in cortical structures such as membrane ruffles and lamellipodia. The properties of cortactin indicate its importance for microfilament-membrane interactions as well as transducing signals from the cell surface to the cytoskeleton. Human cortactin gene is localized on chromosome 11q13. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.01-0.03ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse and Rat Brain lysates Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7901-85L
Reactivities: Mouse
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 1992 Feb;7(2):355-61 PMID: 1532244.
Additional info: Recognizes mouse Cortactin. Species sequence homology: bovine, canine, human, rat.

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