Cortisol

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution: \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C7904-08

Size

1mg

Applications

ELISA

Hosts

Mouse

Form

Supplied as a liquid in PBS, pH 7.15, 0.05% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

Additional Info

Recognizes human cortisol. Crossreactivity: Corticosterone: 45%; Progesterone: 9%; Deoxycortisol, Dexamethazone: < 2%; Estrone (E1), Estriol (E3), Testosterone: < 0.01%.