Cotinine

Cat no: C7904-51B

Supplier: United States Biological

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Additional Information

Cotinine is an alkaloid found in tobacco and is also a metabolite of nicotine. The word "cotinine" is an anagram of "nicotine". Cotinine has an in vivo half-life of approximately 20 hours, and is typically detectable for several days (up to one week) after the use of tobacco. The level of cotinine in the blood is proportionate to the amount of exposure to tobacco smoke, so it is a valuable indicator of tobacco smoke exposure, including secondary (passive) smoke.[3] People who smoke menthol cigarettes may retain cotinine in the blood for a longer period because menthol can compete with enzymatic metabolism of cotinine.[4] Genetic encoding of liver enzymes may also play a role.) It is used as a biomarker for exposure to tobacco smoke and has also been sold as an antidepressant under the brand name Scotine. Applications: Suitable for use in ELISA, Western Blot, Dot Blot, Immunohistochemistry, Immunoassays, development of rapid tests and other antibody recognition assays. Other applications not tested. Recommended Dilution: ELISA: 2.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C7904-51B
Hosts:	Sheep
Applications:	ELISA, Immunohistochemistry, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 20mM phosphate, 150mM sodium chloride, pH 7.2, 0.09% sodium azide.
P type:	Pab
Isotype:	IgG
Purity:	Purified by ammonium sulfate precipitation.
References:	1. David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/books?id=DeX7jgInYFMC&lpg=PA522&dq=scotine%20cotinine&as_brr=3&pg=PA522#v=onepage&q=&f=false.. 2. Dwoskin LP, Teng L, Buxton ST, Crooks PA (March 1999).
Additional info:	Recognizes cotinine.

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Cotinine

Cat no: C7904-51B

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