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CP-100356 Hydrochloride

Cat no: 007084


Supplier: United States Biological
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CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM). Form: Off-White to Light Tan Solid Melting Point: 210-212 degrees C Solubility: Chloroform, Methanol Pfizer Compound
Catalogue number: 007084
Size: 10mg
Form: Off-White to Light Tan Solid
Alternative names: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine Monohydrochloride;
References: Ayrton, A., et al.: Xenobiotica, 31, 469 (2001), Mizuno, N., et al.: Pharmacol. Rev., 55, 425 (2003), Fojo, T., et al.: Clin. Breast Cancer, 7, 749 (2007), Polli, J., et al.: Drug Metab. Dispos., 36, 695 92008),

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