CPN1 (Carboxypeptidase N Catalytic Chain, CPN, Carboxypeptidase N Polypeptide 1, Lysine Carboxypeptidase, Arginine Carboxypeptidase, Kininase-1, Serum Carboxypeptidase N, SCPN, Anaphylatoxin Inactivator, Plasma Carboxypeptidase B)

Carboxypeptidase N is a plasma metallo-protease that cleaves basicaa from the C terminal of peptides and proteins. CPN1 is important in the regulation of peptides like kinins and anaphylatoxins, and it has also been known as kininase-1 and anaphylatoxin inactivator. It is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; CPN1 is the catalytic subunit. Mutations in this protein can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency (1).\nNote: The 48kD form is generated by proteolytic cleavage at the C-terminus. This subunit is cleaved into a peptide of 27kD (2).\n\nApplications:\nSuitable for use in Western Blot and Immunocytochemistry. Other applications have not been tested. \n\nRecommended Dilutions: \nWestern Blot: 1:1000-1:10,000 \nImmunocytochemistry: 1:100-1:250\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

C1209-55A

Size

100ul

Applications

ICC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.

P Type

Mab

Purity

Supernatant

References

1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8. 2. Quagraine et al. Biochem J. 2005 May 15;388(Pt 1):81-91.S

Additional Info

Recognizes human CPN1.