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CREB 1 (cAMP responsive element binding protein 1)

CREB 1 (cAMP responsive element binding protein 1)

Cat no: C7915-16B

Supplier: United States Biological
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CREB is a transcription factor which binds to cyclic AMP response elements (CRE's), and is induced by phosphoyrlation on the part of PKA, CaM K IV, and other protein kinases. Activated CREB will dimerize, bind to DNA, and recruit histone acetyl transferases. Applications: Suitable for use in GS, ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7915-16B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 100ul
Form: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7
P type: Pab
Isotype: IgG
Purity: Purified
References: This product has been used in:Lemasson I et al. Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells. J Biol Chem 277:49459-65 (2002). Moreno CS et al. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 10:143-51 (1999).
Additional info: Anti-CREB-1 (p43) may react non-specifically with other proteins. A partial crossreactivity is observed against CREM-1 protein. Species Crossreactivity: Crossreacts with Human, Mouse and Rat.

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