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CREB, phosphorylated (Ser121) (CBP, CREBBP, CREB binding protein, cAMP Response Element Binding Protein, RTS, RSTS, Rubinstein-Taybi syndrome)

CREB, phosphorylated (Ser121) (CBP, CREBBP, CREB binding protein, cAMP Response Element Binding Protein, RTS, RSTS, Rubinstein-Taybi syndrome)

Cat no: C7915-01J

Supplier: United States Biological
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Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. CREB is also regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 by the ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7915-01J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: As reported
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: CBP, CREBBP, CREB binding protein, cAMP Response Element Binding Protein, RTS, RSTS, Rubinstein-Taybi syndrome
References: 1. Shi. Y., et al. Direct regulation of CREB transcriptional activity by ATM in response to DNA damage. PNAS. 101: 5898-5903 (2004) 2. Dodson, G.E., & Tibbetts, R.S. DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J. Biol. Chem. 281:1692-1697, 2006. 3. Shanware, N. P., Trinh, A. T., Williams, L. M., and Tibbetts, R. S. (2007) Coregulated Ataxia Telangiectasia-mutated and Casein Kinase Sites Modulate cAMP-response Element-binding Protein-Coactivator Interactions in Response to DNA Damage, 282, 6283-6291. 4. Shi, Y., Dodson, G. E., Mukhopadhyay, P. S., Shanware, N. P., Trinh, A. T., and Tibbetts, R. S. (2007) Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies, 282, 9236-9243.
Additional info: This antibody is specific for the Ser-121-phosphorylated form of CREB. Species Crossreactivity: Reacts with human and mouse CREB. Other species have not been tested.

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