CREB3, NT (CREB3, LZIP, Cyclic AMP-responsive element-binding protein 3, Leucin zipper proitein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3) (Azide free) (HRP)

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze horseradish peroxidase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034204-HRP

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). Conjugated to HRP.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Kim, H.C., et al. Cell. Mol. Life Sci. 67(20):3499-3510(2010)\nEleveld-Trancikova, D., et al. Mol. Immunol. 47 (11-12), 1963-1973 (2010) :\nKang, H., et al. Mol. Endocrinol. 23(11):1746-1757(2009)\nMamdani, F., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (4), 500-504 (2008) :\nAudas, T.E., et al. Mol. Cell. Biol. 28(12):3952-3966(2008)

Additional Info

Human

Alternative Names

CREB3, LZIP, Cyclic AMP-responsive element-binding protein 3, Leucin zipper proitein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3