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CRELD1, Recombinant, Mouse (Cysteine-rich Protein With EGF-like Domains 1, AVSD2)

Cat no: 167641


Supplier: United States Biological
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Cysteine�rich with EGF�like domain protein 1 (CRELD1) is an ~50kD transmembrane glycoprotein that contains a 333aa extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15aa (1). Within the large ECD, mouse and human CRELD1 share 92%aa sequence identity. CRELD1 is widely expressed during development and in the adult (1). It interacts with Reticulon 3/RTN3 and inhibits the pro�apoptotic activity of RTN3 (2). CRELD1 also associates with Adrenergic alpha�1 receptors in the prostate and limits their expression (3). Missense mutations of human CRELD1 are associated with susceptibility to atrioventricular septal defects in the heart (4). Source: Recombinant corresponding to aa30�362 from mouse CRELD1 at C-terminal, expressed in NS0 cells (Q91XD7). Molecular Weight: ~37.1kD Biological Activity: Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.3-1.5ug/ml. Endotoxin: <0.10 EU per 1ug of protein by the LAL method Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 167641
Reactivities: Mouse
Size: 50ug
Form: Supplied as a lyophilized powder in PBS. Reconstitute with sterile PBS.
Purity: ~95% (SDS-PAGE)
References: 1. Rupp, P.A. et al. (2002) Gene 293:47. 2. Xiang, R. and S. Zhao (2009) Mol. Cell. Biochem. 331:225. 3. Nishimune, A. et al. (2010) J. Pharmacol. Sci. 113:169. 4. Robinson, S.W. et al. (2003) Am. J. Hum. Genet. 72:1047.

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