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CREM (cAMP responsive element modulator, hCREM 2, ICER, Inducible cAMP early repressor)

CREM (cAMP responsive element modulator, hCREM 2, ICER, Inducible cAMP early repressor)

Cat no: C7919-01A

Supplier: United States Biological
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This antibody recognizes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7919-01A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: cAMP responsive element modulator, hCREM 2, ICER, Inducible cAMP early repressor
References: Tenbrock K et al. The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. J Immunol 170:2971-6 (2003). PubMed: 12626549
Additional info: Species Crossreactivity: Reacts with Human. Predicted to react with Mouse (100% identity with immunogen) and Rat (100% identity with immunogen) due to sequence homology.

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