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CRHR1, aa250-263 (Corticotropin Releasing Hormone Receptor 1, CRHR1, CRF-R, seven transmembrane helix receptor)

CRHR1, aa250-263 (Corticotropin Releasing Hormone Receptor 1, CRHR1, CRF-R, seven transmembrane helix receptor)

Cat no: C7903-79C1

Supplier: United States Biological
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This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Applications: Suitable for use in ELISA, Immunohistochemistry, Western Blot and Immunofluorescence. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:16,000 Western Blot: 1ug/ml Immunohistochemistry: mouse brain Immunofluorescence: mouse brain Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7903-79C1
Reactivities: Human, Mouse
Hosts: Goat
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: seven transmembrane helix receptor, corticotropin releasing hormone receptor variant 1h, CRHR1f, CRHR, CRH-R1h, CRFR1, CRF1, corticotropin releasing hormone receptor 1, CRF-R, CRHR1
References: 1. Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons.Neuron. 2003 Jul 31;39(3):401-7.
Additional info: Recognizes mouse CRHR1. Species sequence homology: human, rat, canine, bovine, sheep.

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