Home  >  Products  >  CRHR2 (Corticotropin-releasing Factor Receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing Hormone Receptor 2, CRH-R-2, CRH-R2, CRF2R, CRH2R)
CRHR2 (Corticotropin-releasing Factor Receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing Hormone Receptor 2, CRH-R-2, CRH-R2, CRF2R, CRH2R)

CRHR2 (Corticotropin-releasing Factor Receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing Hormone Receptor 2, CRH-R-2, CRH-R2, CRF2R, CRH2R)

Cat no: C7903-91C

Supplier: United States Biological
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CRHR2 is a novel member of Secretin-family-GPCR proteins that functions as a functional receptor for CRF. It is expressed as 3 isoforms; alpha, beta and gamma. These isoforms primarily differ in their N-terminal sequence and tissue distribution. Apart from CRF, other ligands of CRHR2 include UcnI, UcnII and UcnIII. CRHR2 is involved in stress responses, cardiovascular function and gastric motility. Studies on CRHR2 deficient mice suggested a central anxiolytic effect of CRHR2. Northern Blot analysis detects CRHR2 expression in brain, hypothalamus, heart, GI, lung, skeletal muscle and vasculature. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7903-91C
Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken/Bird
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Bale et.al Ann Rev Pharmacology and Toxicology 44; 525-557 (February 2004). 2. Kishimoto et.al Nat Genet 24, 415-419 (2000).
Additional info: Recognizes human CRHR2. Species Crossreactivity: bovine, chicken, canine, mouse, rat. Species sequence homology: rhesus monkey.

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