CRIM1 may participate in CNS development by interacting with growth factors involved in motor neuron differentiation and survival. It also has a potential role in capillary formation and maintenance during angiogenesis. It also affects BMP processing and delivery to the cell surface. CRIM1 interacts with BMP4 and BMP7. It localises to the cell membrane and is expressed in a number of tissues including the pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver, small intestine and blood vessels. The unprocessed precursor has a length of 1036 amino acids and a predicted molecular weight of 113.7KDa. CRIM1 contains four antistatin-like domains, one IGFBP N-terminal domain and six VWFC domains. It is also N-glycosylated.
Applications:
Suitable for use in Immunohistochemistry, Western Blot and ELISA. Other applications not tested.
Recommended Dilution:
Immunohistochemistry: 3ug/ml
ELISA: 0.03ng/ml.
Optimal dilution determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degrees C. Aliquot and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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